Bachelor of Pharmacy (B.Pharma)
Biopharmaceutics and Pharmacokinetics { BP604T }
All Unit Notes in One PDF

Unit 1
Introduction to Biopharmaceutics
Absorption : Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes,
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

Unit 2
Elimination : Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs
Bioavailability and Bioequivalence : Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.

Unit 3
Pharmacokinetics : Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model. (a). Intravenous Injection (Bolus) (b). Intravenous infusion and (c) Extra vascular administrations. Pharmacokinetics parameters- KE ,t1/2,Vd,AUC,Ka, Clt and
CLR- definitions methods of eliminations, understanding of their significance and application

Unit 4
Multicompartment models : Two compartment open model. IV bolus
Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.

Unit 5
Nonlinear Pharmacokinetics :
a. Introduction,
b. Factors causing Non-linearity.
c. Michaelis-menton method of estimating parameters, Explanation with example of drugs.

Biopharmaceutics and Pharmacokinetics Unit 5 Notes

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Biopharmaceutics and Pharmacokinetics
Unit 5 Notes