Medicinal Chemistry III
Unit 2 Notes

Antibiotics
Historical background, Nomenclature, Stereochemistry, Structure activity
relationship, Chemical degradation classification and important products of the following classes.
Macrolide : Erythromycin Clarithromycin, Azithromycin.

Miscellaneous : Chloramphenicol*, Clindamycin.

Prodrugs : Basic concepts and application of prodrugs design.

Antimalarials : Etiology of malaria.

Quinolines : SAR, Quinine sulphate, Chloroquine, Amodiaquine, Primaquine phosphate, Pamaquine, Quinacrine hydrochloride, Mefloquine.

Biguanides and dihydro triazines : Cycloguanil pamoate, Proguanil.

Miscellaneous : Pyrimethamine, Artesunete, Artemether, Atovoquone.

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